Selective Internal Radiation Therapy
SIR-Spheres Resin Microspheres
Personalised predictive dosimetry by Artery-Specific SPECT/CT Partition Model. Worked examples courtesy of Singapore General Hospital.
Video Overview of SIRT Predictive Dosimetry 2022 Theranostics Course, Australia
Concept Overview (SNM 2011 poster), courtesy Singapore General Hospital
Kao et al. Journal of Nuclear Medicine May 2011, 52 (supplement 1) 1084
Kao et al. Scientific basis of personalised tomographic radiation planning for radioembolisation: A form of brachytherapy planning.
J Med Imaging Radiat Oncol. 2015;59:617-618
Artery-Specific SPECT/CT Partition Model
Kao et al. Image-guided personalized predictive dosimetry by artery-specific SPECT/CT partition modeling for safe and effective 90Y radioembolization.
Lung Shunt & Mass by SPECT/CT
Kao et al. Personalized predictive lung dosimetry by technetium-99m macroaggregated albumin SPECT/CT for yttrium-90 radioembolization.
Dose-Response Guidance
Kao YH. Dose-response for yttrium-90 resin microsphere radioembolisation.
Y-90 PET Diagnostic Criteria
Kao et al. Post-radioembolization yttrium-90 PET/CT - part 1: diagnostic reporting. EJNMMI Res. 2013;3:56
Y-90 PET Absorbed Dose Verification
Kao et al. Post-radioembolization yttrium-90 PET/CT - part 2: dose-response and tumor predictive dosimetry for resin microspheres.
Y-90 PET for Residual Activity
Kao et al. 90 Y PET for Qualitative and Quantitative Assessment of Residual Activity in Delivery Apparatus After Radioembolization.
1. MIRD Method
2. Partition Model
3. Theranostic Surrogate
4. Conceptual problems with BSA Method
5. Soluble Contrast Molecules cannot simulate Particles
6. Interventional Radiology
1. MIRD Method
Toohey et al. The AAPM/RSNA physics tutorial for residents: internal radiation dosimetry: principles and applications.
Radiographics. 2000;20:533-546
2. Partition Model
Ho et al. Partition model for estimating radiation doses from yttrium-90 microspheres in treating hepatic tumours.
Eur J Nucl Med. 1996;23:947-952
3. Theranostic Surrogate
Kao YH. A clinical dosimetric perspective uncovers new evidence and offers new insight in favor of 99mTc-macroaggregated albumin for predictive dosimetry in 90Y resin microsphere radioembolization.
4. Conceptual Problems with BSA Method
Kao et al. Clinical implications of the body surface area method versus partition model dosimetry for yttrium-90 radioembolization using resin microspheres: a technical review.
Kao YH. Results confounded by a disregard for basic dose-response radiobiology.
Kao YH. Disregard for Basic Dosimetric Principles Will Lead to Questionable Results.
Kao et al. Origin, dosimetric effect and clinical limitations of the semi-empirical body surface area method for radioembolisation using yttrium-90 resin microspheres.
J Med Imaging Radiat Oncol. 2016;60:382-385
5. Soluble Contrast Molecules cannot simulate Microparticles
Kao et al. Imaging discordance between hepatic angiography versus Tc-99m-MAA SPECT/CT: a case series, technical discussion and clinical implications.
6. Interventional Radiology
Salem et al. Radioembolization with 90Yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies.
Part 1: Technical and methodologic considerations.
J Vasc Interv Radiol. 2006;17:1251-1278
Part 2: Special topics.
J Vasc Interv Radiol. 2006;17:1425-1439
Part 3: Comprehensive literature review and future direction.
Radioembolisation to sites other than the Liver
Kao YH. General Theory of Predictive Dosimetry for Yttrium-90 Radioembolization to Sites Other than the Liver.
Cardiovasc Intervent Radiol. 2014;37:1114-1117
Tumour-to-Lung Shunt: conventional Liver-to-Lung Shunt formularism is only partially correct, sometimes completely wrong
Kao YH. Dosimetric theory for tumor-to-lung shunt fraction calculation in yttrium-90 radioembolization of noncirrhotic livers.
Nucl Med Commun. 2014;35:331-332
The Holy Gray
Kao YH. Yes, the Holy Gray exists. Learn from modern radioembolisation.
Eur J Nucl Med Mol Imaging. 2021;48:4115-4117
Rapid Predictive Dosimetry
Kao YH. Rapid predictive dosimetry for radioembolization.